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KMID : 0378019770200070083
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New Medical Journal
1977 Volume.20 No. 7 p.83 ~ p.86
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Clinical Observations on the Effectiveness of Solantal (Tiaramide) on Upper Respiratory Infections
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한용철/Han, Yong Chol
노수환/윤광선/강홍모/김선영/허성호/김유영/Rho, Soo Whan/Yun, Kwang Sun/Kang, Hong Mo/Kim, Sun Young/Hue, Sung Ho/Kim, You Young
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Abstract
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Clinical trial on the effectiveness of “Solantal” (Tiaramide.HCI) in upper respiratory infections was conducted. Fifty subjects, 30 male and 20 female consisting of the medical staffs, nursing staffs, and their families of the Seoul National University Hospital, with upper respiratory infections, and patients admitted to the same hospital with diseases other than respiratory origin who started to have symptoms during their admission. The clinical diagnoses on these 50 subjects were; influenza in 5, nasopharingitis in 35, tonsilitis in 2 and acute bronchitis in 6. Mean age of the subjects is 36.6 years old.
The patients were given 300-600mg. of Tiaramide HCI per day in three divided dosages through oral route. The average duration of treatment was 4.25 days.
Pre-and post-treatment status were compared on the following ten items, i. e. headache, odynophagia, sore throat hoarseness, cough, sputum, rhinorrhea, lassitude, arthralgia and fever, and the effectiveness was evaluated into 9 categories, i. e. excellent, good, fair, poor, worse and unknown. The ratio of excellent plus good to total number of patients who were suffered from each symptom is followings.
1) headache 75% 2) odynophagia 67% 3) sore throat 80.5%
4) hoarseness 58.3% 5) cough 57.5% 6) sputum 57.6%
7) rhinorrhea 81.5% 8) lassitude 67.5% 9) arthralgia 50% 10) fever 67.6%
The tentative conclusions, pending more accurate double blind tests, are that Solantal
has excellent anti-inflammatory action in upper respiratory infections, along with some analgesic and antipyretic actions.
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